Muscle X Edge Reviews

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Brian Green
By Brian Green
July 1, 2013

Muscle X Edge is a pre-workout supplement advertised to improve gym performance by boosting nitric oxide production. It contains four natural ingredients specifically chosen to achieve this goal.

While using nitric oxide for improving performance isn’t a new concept, Muscle X Edge is nonetheless generating a lot of hype in bodybuilding

Muscle X Edge’s Active Ingredients

Muscle X Edge provides the following intended to raise athletic performance and improve muscle development.

Arginine Alpha-Ketoglutarate (AAKG) (2985 mg)
AAKG is advertised to increase nitric oxide production, resulting in better physical performance and muscle development.

However, clinical research does not back these claims. One 2011 clinical trial shows AAKG does not improve muscle endurance and may even hinder physical performance.[1]

In addition, a clinical study involving 24 individuals shows AAKG did not increase nitric oxide production or vasodilation.[2]

Ornithine Alpha-Ketoglutarate (OKG) (75 mg)
OKG is an amino acid proven in clinical studies to lower protein catabolism after muscle injury, slowing down muscle breakdown and facilitating recovery.[3][4]

Clinical evidence shows 20 mg OKG has a significant effect on muscle development so Muscle X Edge’s 75 mg dose is likely to produce similar results.

Alpha-Ketoisocaproic Acid (AKIC) (75 mg)
AKIC is involved in the metabolism of amino acids. Though companies advertise it as a performance stimulator, clinical studies disagree.

For example, the results of a 2007 clinical trial on AKIC’s effect on exercise performance show AKIC does not alter physical performance.[5]

Glutamine-Alpha-Ketoglutarate (GKG) (15 mg)
Many athletes take GKG to improve athletic performance. However, clinical research supporting this use is limited to intravenously supplemented GKG to dialysis patients.[6]

Will Muscle X Edge Cause Side Effects?

Muscle X Edge’s ingredients don’t appear to cause negative side effects. However, not enough information is known about how these ingredients affect growing individuals and infants; consequently, teenagers and pregnant women should avoid taking Muscle X Edge.

Purchasing Muscle X Edge

Muscle X Edge is exclusively sold directly from the manufacturer at It appears the company initially offers a 14-day trial of the product that runs from the order date. After 14 days, the company charges $79.99 for the product.[7]

The trial also comes with an auto-ship program, so you receive a new bottle once a month for $79.99.[7]

If you want to try Muscle X Edge but don’t want to sign up for a monthly shipping program, another option is to buy the product from third-party sellers on

Is There a Guarantee?

Muscle X Edge accepts returns on unopened products, minus a $10 restocking fee.[7]

To return a product, contact the company at 1-860-613-0883 or [7]

Final Thoughts on Muscle X Edge

Muscle X Edge is a mixed bag. It does provide an impressive amount of OKG, an ingredient proven to ensure good muscle development and maintenance. However, many of Muscle X Edge’s other ingredients are not as proven. Consequently, the product’s total effectiveness is debatable.

The product may work for you but I would wait for more user reviews before pulling the trigger on Muscle X Edge.


[1] Greer, Beau K., and Brett T. Jones. “Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training.” The Journal of Strength & Conditioning Research, 25.7 (2011): 1789-1794.

[2] Willoughby, Darryn S., et al. “Effects of 7 days of arginine-alpha-ketoglutarate supplementation on blood flow, plasma L-arginine, nitric oxide metabolites, and asymmetric dimethyl arginine after resistance exercise.” International Journal of Sport Nutrition and Exercise Metabolism, 21.4 (2011): 291.

[3] Cynober, L. “Ornithine alpha-ketoglutarate in nutritional support.” Nutrition, 7.5 (1991): 313.

[4] Cynober, Luc, et al. “Effect of enterally administered ornithine alpha-ketoglutarate on plasma and urinary amino acid levels after burn injury.” The Journal of Trauma and Acute Care Surgery, 24.7 (1984): 590-596.

[5] Yarrow, Joshua F., et al. “The effects of short-term alpha-ketoisocaproic acid supplementation on exercise performance: a randomized controlled trial.” Journal of the International Society of Sports Nutrition, 4.1 (2007): 1-6.

[6] “Alpha-Ketoglutarate Overview Information.” Accessed 6.17.2013. WebMD discusses alpha-ketoglutarate

[7] “Muscle X Edge Terms.” Accessed 6.17.2013.

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