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Synedrex Reviews

Community Rating:

3.2 / 5.0

Editor's Rating:

3.7 / 5.0
Derek Peterson
By Derek Peterson
March 10, 2010

Synedrex is a fat-burning diet pill from Metabolic Nutrition said to combine natural ingredients to burn fat. With a 1-capsule dosage, manufacturers say Synedrex increases caloric expenditure, raises energy, enhances focus, and suppresses appetite.

The result?

According to Metabolic Nutrition, it’s “the most powerful one dose daily thermogenic.”

But everyone knows that outrageous advertising claims fool no one. Let’s dive below this glossy surface and see where the Synedrex current really takes us.

What’s in the Synedrex Formula?

According to Metabolic Nutrition, Synedrex’s weight loss benefits come from its 815 mg proprietary blend. This blend contains 13 natural ingredients that stimulate the central nervous system to increase metabolism and burn fat.

I’m not normally a fan of proprietary blends because they disguise real ingredient dosages, making it hard to tell if each ingredient is included in a safe and effective amount. But perhaps Metabolic Nutrition chose to list Synedrex ingredients in a proprietary blend to protect its formula from competitors.

Operating under that optimistic assumption, I’ll consider a few ingredients in this blend.


When the FDA banned ephedra, many diet pill companies turned to synephrine for its similar chemical structure and effect on fat burning. While anecdotal evidence supports synephrine’s effectiveness as a fat burner, it still causes side effects that may be too strong for many dieters. This is a big risk to take for an ingredient that remains largely untested [1].

Green Tea Extract

Like synephrine, green tea is a central nervous stimulant that sparks thermogenesis and burns fat. However, it is largely without synephrine’s potent side effects. When green tea is included in 300-600 mg doses, it triggers an average 30-pound weight loss [2]. Unfortunately, the proprietary blend in Synedrex prevents me from confirming green tea is present in its recommended dosage.


Another stimulant, yohimbine burns fat by creating heat and boosting metabolism. In 1991, test subjects in a scientific study lost an average 7.82 pounds while taking yohimbine [3]. Unfortunately, it too comes with unwanted side effects. It’s considered especially dangerous alongside caffeine, which may make green tea’s inclusion in Synedrex a bit precarious [4].

1, 3 Dimethylamylamine

1, 3 dimethylamylamine is a synthetic compound that progressed from a commonly-used nasal decongestant to a popular weight loss supplement. Although may say 1, 3 dimethylamylamine is a potent fat burner, its powerful side effects led to its FDA ban in 2012 [5].

Alpha Lipoic Acid (ALA)

Commonly used in skin care supplements, alpha lipoic acid is an antioxidant that prevents cell damage. According to a 2011 study, ALA also decreases body fat by treating diabetes and high blood pressure [6]. However, it would be nice to see a little more research on ALA before it’s fully embraced as a weight loss aid.

This ingredient profile is among the most potent I’ve seen. As a stimulant-based diet pill, Synedrex definitely succeeds. While I’m concerned about the lack of explicit information on ingredient dosage, the ingredients in Synedrex will likely provide weight loss for most users.

Unfortunately, the route to that weight loss may not be appealing. Many of these ingredients cause severe side effects that aren’t explored in Synedrex advertisements. I intend to explore them myself now.

Is Synedrex Safe?

Any time you rely on potent stimulants to help you lose weight, you’re going to experience side effects. Considering the Synedrex formula, I’d say the side effect possibility with this supplement is even higher than usual.

The biggest problem with the Synedrex formula is 1, 3 dimethylamylamine. This ingredient was banned by the FDA for a reason. According to WebMD, 1, 3 dimethylamylamine increases risk of heart attack and stroke by raising heartbeat and blood pressure [7]. The FDA banned the ingredient after several incidents of cardiac problems and even death were reported [5]. Clearly, this isn’t anything you want to mess around with.

Another problem ingredient is synephrine. While it’s marketed as a safe alternative to ephedrine, there’s not much safe about it for most people. Like 1,3 dimethylamylamine, it is linked to high blood pressure, increased heart rate, fainting, heart attack, and stroke.

Yohimbine often causes the same side effects and is considered especially dangerous when combined with caffeine, as it is here. In fact, many scientific researchers studying anxiety use the yohimbine and caffeine combination to induce the condition in test subjects [4].

With so many stimulants, I’m very worried about Synedrex’s safety profile. To see what it’s like for real customers, let’s take a look at some customer reviews.

What Do Customers Think?

Synedrex customer reviews on bear out my own conclusions: that Synedrex is an effective fat burner, but causes intense side effects. In fact, many of the 43 reviewers said they were “scared of” Synedrex, but found it difficult to argue with the resulting weight loss.

Here’s what a few such customers had to say about their weight loss experience with Synedrex.

“First sign, overwhelming energy. I just wanted to get up and do something! Then my body felt like it was heating up. About 2 hours in, I feel really dizzy and nauseous. I had to focus really hard to not vomit. When I got up and walked around, I had an overwhelming feeling of the room spinning. With the dramatic loss in appetite, I didn’t want to eat or drink either. This dizzy/nausea feeling lasted about 2 hours. After that, it was constant energy for another 6-8 hours. I’m quite frankly scared of these pills lol MAKE SURE YOU EAT! “—Chris Ace

“i was scared too! i had trouble sleeping last night when i took it at 10.” –Alexa

“It definatly suppressed my appetite, and within 5 days I had lost 5 pounds. Then into the second week, I was laying in bed, and my muscle in my leg started twitching… I was freaking out all night long…i would also get slight chest pangs, left arm and jaw…so I was nervous about that as well. Then I made the mistake of taking 2 one day as I was going to the gym and wanted some extra energy…. I stopped early on the eliptical when I realized my HR was almost 200. This is definatly not a supplement to mess around with….” –J.A. Larko “shoppin mommy”

“I took for first time at 6:00 Am with food. Made me extremely nauseated and vomiting. May be great product for some I guess I have a very sensitive system. I have jitters and feel very warm as others have reported. I took one capsule. I regularly workout, there is no way I can today.” –Loyc

As you can see, Synedrex is an effective diet pill that comes with a very high price—your health. Of course you’ll lose weight if you feel too sick to eat. The question is whether or not it’s worth it. Hopefully, your answer is no.

How Much Does Synedrex Cost?

On the official Metabolic Nutrition website, you can get a 45-day supply of Synedrex for $59.99. Manufacturers recommend you take 1 capsule a day, so each bottle lasts about a month and a half. However, Synedrex is currently listed as “out of stock” on

You can keep checking back, or order from websites like:
Price: $31.99
Price: $32.93
Price: $39.75

Advantage Supplements
Price: $44.99

Price: $44.99

This is a fairly average price for a diet pill. The deals on eBay and VitaDigest make it even better. However, the dangerous side effects associated with Synedrex make the benefits from a low price negligible.

Should You Try Synedrex?

Synedrex definitely contains some effective weight loss ingredients, but unless you think lying in bed and feeling nauseous is the ideal weight loss program, I don’t recommend it.

If you’re very tolerant of stimulants and have used a product like this in the past, you may like Synedrex. However, I don’t recommend gambling your health for the sake of fast weight loss.


[1] Haaz, S., K.R. Fontaine, G. Cutter, N. Limdi, S. Perumean-Chaney, and D.B. Allison. 2006. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity Reviews: Vol. 7, Issue 1.

[2] Di Pierro, Francesco, Anna Borsetto Meghi, Angela Barreca, Maurizio Lucarelli, Andrea Calandrelli. 2009. GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review: Vol. 14, Issue 2.

[3] Kuehne, Martin and Randy Muth. 1991. Total syntheses of yohimbe alkaloid, with stereoselection for the normal, allo, and 3-epiallo series, based on annelations of 4-methoxy-1,2-dihydropyridones. Journal of Organic Chemistry: Vol. 56, Issue 8.

[4] 2013. Yohimbe. bine+%28YOHIMBE%29&source=2.

[5] The U.S. Food and Drug Administration. April 2013. Stimulant Potentially Dangerous to Health, FDA Warns.

[6]Koh, E.H., W.J. Lee, E.H. Kim, E.H. Cho, E. Jeong, D.W. Kim, M.S. Kim, J.Y Park, K.G. Park, H.J. Lee, I.K. Lee, S. Lim, H.C. Jang, K.H. Lee, and K.U. Lee. 2011. Effects of alpha-lipoic acid on body weight in obese subjects. The American Journal of Medicine: Vol. 124, Issue 1.

[6] 2013. Dimethylamylamine.

User Submitted Reviews

5 out of 9 (56 %) Reviewers Recommend This Product

Community Rating:
3.2 / 5.0


roshena andrews | August 18, 2014

I have been taking this product for four days and I have lost 7 pounds after two days. I have not weighed my self again yet. Is this product strong Yes, it is. I think we all need to we wise in everything we do. I am planning to continue this product until I get to my goal weight. Will have to to miss a day or two and watch the signs of my body?Yes. It works. I have been eating only 400 to 800 calories a day. I have been making good choices and healthy choices. When I get to my goal weight my goal is to learn to make healthy choices and become a good eater.This product is giving me that option and I am liking it. I am experiencing the side effects but I am pacing my self and listening to my body. If it was so easy for me to change I would not need this product. So. I recommend this product but tell you to listen to your body and make the necessary adjustments.

Yes, I recommend this product

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Tammy | July 17, 2014

I have been taking this for about 3-4 weeks now and am not sure how I feel about it. The amount of energy it gives me is great!!! The first couple of hours I am very amped up, but don’t like how bad I sweat for that period of time. What I’m not sure about is that all the other posts talk about the weight people have lost and I haven’t lost a pound, if anything I’ve gained 5 lbs since being on it. I don’t eat a lot, maybe 1,000 calories a day and drink an amazing amount of water daily, so not sure why the weight isn’t coming off. Anyone have any ideas??

Yes, I recommend this product

1 of 1 People Found This Review Helpful

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bb | July 15, 2014

This product does make you feel hyped up but you just need to find something to do with your extra energy working out at home everyday works as well as cleaning. You must eat a large meal before taking.and deffiently drink a lot of water throughout the day.I recommend taking vitamins everyday to since you won’t be eating a lot of food, I was weighing at 190 pounds I am now 160. I finished my bottle about 3 months ago and I have decided to buy another bottle to help reach my goal of 120 pounds. I do recommend this product but everybody’s body is different, so try it. Good luck

Yes, I recommend this product

1 of 1 People Found This Review Helpful

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Elaine | May 15, 2014

I’m 5,7 female 300 lbs,This is my first day taking synedrex an I’m feeling really nauseous, light headed, jittery, an can’t focus, is this normal cause I’m kinda scared to keep taking it? I feel like I’m high.

No, I do not recommend this product

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carlos | October 7, 2013

I’m 28 year I have been taking this product for the past 2weeks.I noticed I lost a totaL10 has it bad side effect you feel very panicky.very hard to fall asleep at night.I consider myself very sexually active i haven’t had problem having an erection.but since I’ve been taking this product I have lost my sexual drive.has anyone else experienced this.I honestly don’t recommend there’s no pill out there worth losing your sex life!

No, I do not recommend this product

1 of 1 People Found This Review Helpful

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GG | September 20, 2013

I should start by saying, I have a very high tolerance to fat burners. I took the old version of OxyElite Pro well over a year to shed by baby weight, and I continued to drink coffee. I cycled off and wanted to try something new, and Synedrex seemed effective. I don’t sweat as much as on the Oxy, I think the appetite suppressant properties are about the same. I felt a touch blue the first day I took Synedrex, but that has gone away. It gives me energy, however I can feel my heart rate increase once I’ve taken it. I only take 1 pill a day, on an empty stomach about 7 AM. It has affected my sleep a little. I also feel a little nauseas about an hour after I take it, but that also goes away, nothing close to actually being sick. None of these products are good for you, and because of the stress it puts your body under, I never work out on it; I work out in the evenings. I think if you have a good tolerance to stimulants it will work for you, but listen to your body and drink a lot of water. Definitely cycle off when you’re supposed to or it will downgrade your adrenals too much. I think it’s an effective product, and will take the entire bottle. I would also consider giving your body a break on the weekends.

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Watchful Eye | July 13, 2013

I have taken a handful of other fat burners, I work out ALOT and eat and drink plenty. I noticed I lost body fat, and carved some muscles but also noticed popping veins and terrible headaches. I also noticed bad moods, and irritability as well as just an overwhelming depressed feeling after the product wore off. Personally I would suggest being careful, I have stopped taking it and my world turned back around and I feel better again so its something that worries me want to share my experience with others. Again I have taken other thermogenics that are popular on the market, without the same problems so just be careful and watch out for these signs!

No, I do not recommend this product

1 of 1 People Found This Review Helpful

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Karlie | July 2, 2013

It is my second day taking synedrex and I love it! The only bad thing is, that if you’re sensitive to caffeine you might feel a bit nauseous or too energetic. I got sweaty palms and dry mouth, but I lost 2 pounds already. I am 134 and went to 132 in 2 days. I work out 5 days a week and eat pretty healthy but this stuff helps give you that extra boost so you can lose weight more easily. I am going to Puerto Vallarta in 19 days so we’ll see if I am slimmer by then. I have a ridiculous amount of energy and I am not as hungry, which is not normal for me because I’m a snacker. The only main recommendation I have for new people wanting to try this is to drink lots of water and to not consume any other caffeine….it works! Good luck!!

Yes, I recommend this product

1 of 1 People Found This Review Helpful

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hunter | May 28, 2013

Ok so yes this product works but I’m not sure if it is safe. I weighed 206 twp weeks ago I now weigh 184.. sounds great but I’m so unhealthy feeling. Today I took a different pill that also has yohibimine in it without thinking I took the synedrex as well. I’ve been violently puking for hours! I highly suggest this to be banned by FDA!! IM seriously questioning if I showed call 911 its 94º I’m freezing and sweating andlike I said viloently puking my ribs feel broken

No, I do not recommend this product

1 of 1 People Found This Review Helpful

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Paul | April 8, 2013

I bought this product about a three weeks ago at a local nutrition shop from day one i could tell a huge difference in my appetite. I normally consume about 5 to 6 thousand calories a day and it has deystroyed my appetite. I am averaging about 1500 calories a day now and that is foeced. The only downside to this product is that food never sounds good no matter how hungry I get even my favorite foods disgust me. I take two a day I once made the mistake of doubling up and felt like I was gonna pass out. I have also been able to cut my energy drink habit down from about three a day to one or none.

Yes, I recommend this product

1 of 1 People Found This Review Helpful

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Ash | January 3, 2013

I have been taking it for about a weeks so far and the only complications I have had was not being able to fall asleep during the first 3 days of taking it. It completely controls my hunger and it also gives me a ton of energy! I have lost a noticeable amount of weight in just one week!

4 of 4 People Found This Review Helpful

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RR | August 21, 2012

Took one pill of Synedrex on a full stomach, Large Salad w/ Ranch, Tall glass of orange juice, plenty of water.

3 hours pass, feeling invigorated like all the caffeine I’ve taken throughout my life was given to me all at once.

Hours 4 hits, massive nausea hits, puke up the entire day’s content of seriously digested food, 2:19a over 5 hours later, still puking. Bottom of my stomach contents contains coated in blood. What have I done to myself??? Searching my room for bottle of Activated Charcoal I’m misplaced. Unable to locate. Try putting ice on stomach, Massive fever, currently wondering if I should go to the hospital or contact Poison Control. Will post again when finish going through hell.

3 of 5 People Found This Review Helpful

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