Synedrex is a fat-burning diet pill from Metabolic Nutrition said to combine natural ingredients to burn fat. With a 1-capsule dosage, manufacturers say Synedrex increases caloric expenditure, raises energy, enhances focus, and suppresses appetite.
According to Metabolic Nutrition, it’s “the most powerful one dose daily thermogenic.”
But everyone knows that outrageous advertising claims fool no one. Let’s dive below this glossy surface and see where the Synedrex current really takes us.
What’s in the Synedrex Formula?
According to Metabolic Nutrition, Synedrex’s weight loss benefits come from its 815 mg proprietary blend. This blend contains 13 natural ingredients that stimulate the central nervous system to increase metabolism and burn fat.
I’m not normally a fan of proprietary blends because they disguise real ingredient dosages, making it hard to tell if each ingredient is included in a safe and effective amount. But perhaps Metabolic Nutrition chose to list Synedrex ingredients in a proprietary blend to protect its formula from competitors.
Operating under that optimistic assumption, I’ll consider a few ingredients in this blend.
When the FDA banned ephedra, many diet pill companies turned to synephrine for its similar chemical structure and effect on fat burning. While anecdotal evidence supports synephrine’s effectiveness as a fat burner, it still causes side effects that may be too strong for many dieters. This is a big risk to take for an ingredient that remains largely untested .
Green Tea Extract
Like synephrine, green tea is a central nervous stimulant that sparks thermogenesis and burns fat. However, it is largely without synephrine’s potent side effects. When green tea is included in 300-600 mg doses, it triggers an average 30-pound weight loss . Unfortunately, the proprietary blend in Synedrex prevents me from confirming green tea is present in its recommended dosage.
Another stimulant, yohimbine burns fat by creating heat and boosting metabolism. In 1991, test subjects in a scientific study lost an average 7.82 pounds while taking yohimbine . Unfortunately, it too comes with unwanted side effects. It’s considered especially dangerous alongside caffeine, which may make green tea’s inclusion in Synedrex a bit precarious .
1, 3 Dimethylamylamine
1, 3 dimethylamylamine is a synthetic compound that progressed from a commonly-used nasal decongestant to a popular weight loss supplement. Although may say 1, 3 dimethylamylamine is a potent fat burner, its powerful side effects led to its FDA ban in 2012 .
Alpha Lipoic Acid (ALA)
Commonly used in skin care supplements, alpha lipoic acid is an antioxidant that prevents cell damage. According to a 2011 study, ALA also decreases body fat by treating diabetes and high blood pressure . However, it would be nice to see a little more research on ALA before it’s fully embraced as a weight loss aid.
This ingredient profile is among the most potent I’ve seen. As a stimulant-based diet pill, Synedrex definitely succeeds. While I’m concerned about the lack of explicit information on ingredient dosage, the ingredients in Synedrex will likely provide weight loss for most users.
Unfortunately, the route to that weight loss may not be appealing. Many of these ingredients cause severe side effects that aren’t explored in Synedrex advertisements. I intend to explore them myself now.
Is Synedrex Safe?
Any time you rely on potent stimulants to help you lose weight, you’re going to experience side effects. Considering the Synedrex formula, I’d say the side effect possibility with this supplement is even higher than usual.
The biggest problem with the Synedrex formula is 1, 3 dimethylamylamine. This ingredient was banned by the FDA for a reason. According to WebMD, 1, 3 dimethylamylamine increases risk of heart attack and stroke by raising heartbeat and blood pressure . The FDA banned the ingredient after several incidents of cardiac problems and even death were reported . Clearly, this isn’t anything you want to mess around with.
Another problem ingredient is synephrine. While it’s marketed as a safe alternative to ephedrine, there’s not much safe about it for most people. Like 1,3 dimethylamylamine, it is linked to high blood pressure, increased heart rate, fainting, heart attack, and stroke.
Yohimbine often causes the same side effects and is considered especially dangerous when combined with caffeine, as it is here. In fact, many scientific researchers studying anxiety use the yohimbine and caffeine combination to induce the condition in test subjects .
With so many stimulants, I’m very worried about Synedrex’s safety profile. To see what it’s like for real customers, let’s take a look at some customer reviews.
What Do Customers Think?
Synedrex customer reviews on Amazon.com bear out my own conclusions: that Synedrex is an effective fat burner, but causes intense side effects. In fact, many of the 43 reviewers said they were “scared of” Synedrex, but found it difficult to argue with the resulting weight loss.
Here’s what a few such customers had to say about their weight loss experience with Synedrex.
“First sign, overwhelming energy. I just wanted to get up and do something! Then my body felt like it was heating up. About 2 hours in, I feel really dizzy and nauseous. I had to focus really hard to not vomit. When I got up and walked around, I had an overwhelming feeling of the room spinning. With the dramatic loss in appetite, I didn’t want to eat or drink either. This dizzy/nausea feeling lasted about 2 hours. After that, it was constant energy for another 6-8 hours. I’m quite frankly scared of these pills lol MAKE SURE YOU EAT! “—Chris Ace
“i was scared too! i had trouble sleeping last night when i took it at 10.” –Alexa
“It definatly suppressed my appetite, and within 5 days I had lost 5 pounds. Then into the second week, I was laying in bed, and my muscle in my leg started twitching… I was freaking out all night long…i would also get slight chest pangs, left arm and jaw…so I was nervous about that as well. Then I made the mistake of taking 2 one day as I was going to the gym and wanted some extra energy…. I stopped early on the eliptical when I realized my HR was almost 200. This is definatly not a supplement to mess around with….” –J.A. Larko “shoppin mommy”
“I took for first time at 6:00 Am with food. Made me extremely nauseated and vomiting. May be great product for some I guess I have a very sensitive system. I have jitters and feel very warm as others have reported. I took one capsule. I regularly workout, there is no way I can today.” –Loyc
As you can see, Synedrex is an effective diet pill that comes with a very high price—your health. Of course you’ll lose weight if you feel too sick to eat. The question is whether or not it’s worth it. Hopefully, your answer is no.
How Much Does Synedrex Cost?
On the official Metabolic Nutrition website, you can get a 45-day supply of Synedrex for $59.99. Manufacturers recommend you take 1 capsule a day, so each bottle lasts about a month and a half. However, Synedrex is currently listed as “out of stock” on MetabolicNutrition.com.
You can keep checking back, or order from websites like:
This is a fairly average price for a diet pill. The deals on eBay and VitaDigest make it even better. However, the dangerous side effects associated with Synedrex make the benefits from a low price negligible.
Should You Try Synedrex?
Synedrex definitely contains some effective weight loss ingredients, but unless you think lying in bed and feeling nauseous is the ideal weight loss program, I don’t recommend it.
If you’re very tolerant of stimulants and have used a product like this in the past, you may like Synedrex. However, I don’t recommend gambling your health for the sake of fast weight loss.
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 Di Pierro, Francesco, Anna Borsetto Meghi, Angela Barreca, Maurizio Lucarelli, Andrea Calandrelli. 2009. GreenSelect Phytosome as an adjunct to a low-calorie diet for treatment of obesity: a clinical trial. Alternative Medicine Review: Vol. 14, Issue 2.
 Kuehne, Martin and Randy Muth. 1991. Total syntheses of yohimbe alkaloid, with stereoselection for the normal, allo, and 3-epiallo series, based on annelations of 4-methoxy-1,2-dihydropyridones. Journal of Organic Chemistry: Vol. 56, Issue 8.
 WebMD.com. 2013. Yohimbe. http://www.webmd.com/vitamins-supplements/ingredientmono-759-Yohimbine+YOHIMBE.aspx?activeIngredientId=759&activeIngredientName=Yohim bine+%28YOHIMBE%29&source=2.
 The U.S. Food and Drug Administration. April 2013. Stimulant Potentially Dangerous to Health, FDA Warns. http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm347270.htm.
Koh, E.H., W.J. Lee, E.H. Kim, E.H. Cho, E. Jeong, D.W. Kim, M.S. Kim, J.Y Park, K.G. Park, H.J. Lee, I.K. Lee, S. Lim, H.C. Jang, K.H. Lee, and K.U. Lee. 2011. Effects of alpha-lipoic acid on body weight in obese subjects. The American Journal of Medicine: Vol. 124, Issue 1.
 WebMD.com. 2013. Dimethylamylamine. http://www.webmd.com/vitamins-supplements/ingredientmono-1258-1%2c3+Dimethylamylamine+DIMETHYLAMYLAMINE.aspx?activeIngredientId=1258&activeIngredientName=1%2c3+Dimethylamylamine+%28DIMETHYLAMYLAMINE%29&source=2.