Powerful Fat Burner

Strong results can come with strong side effects

We can’t deny that Alphamine is probably an effective fat burner. However, power usually comes with dangerous side effects, and this is certainly the case with Alphamine. Although it may help you build muscle and burn fat, it may also affect your health.

  • Negative Side Effects
  • Ingredient Quality
  • Value
  • Speed of Results

Many fat burners help you lose weight, but that weight loss doesn’t necessarily equate with fat loss. You may be losing muscle mass along with fat, or simply shedding water weight.

After years of researching the flaws in current fat burners, Physique Enhancing Science (PES) set out to create a more powerful fat burner, known as Alphamine. This weight loss supplement aims to burn fat while still preserving muscle.

We wanted to look a bit deeper into Alphamine to determine whether it could really achieve this amazing feat.

Alphamine Ingredients

Let’s take a look at the individual ingredients that make Alphamine a unique fat burner:

Choline. When you exercise, choline levels in the body are reduced. These levels may reduce the release of the neurotransmitter acetylcholine, which affects endurance and performance. If you replace these choline levels, however, you could potentially perform better athletically.

Studies show improvements in both running times and swimming performances for athletes who took choline prior to exercise. It was concluded that taking choline before strenuous exercise may improve performance and reduce fatigue. [1]

Your body does produce choline naturally, but it can also be found in meat, fish, eggs, dairy, peanuts, broccoli, and Brussels sprouts. A choline excess could lead to side effects such as stomach ache, loose stools or diarrhea, and increased perspiration.

Alpha-Hydroxy-Isocaproic Acid (HICA). HICA, also known as leucic acid, is the product of the metabolism of leucine in muscle (leucine is an amino acid that stimulates muscle protein synthesis). HICA’s anticatabolic properties are supposed to prevent muscle breakdown when energy is released.

One study found that soccer players who took 583 mg HICA 3 times a day for 4 weeks increased body weight and lean body mass, and slightly increased muscle mass. [2]

Eucommia Ulmoides Leaf. This leaf contains 98% chlorogenic acid. Chlorogenic acid is a powerful antioxidant and extremely popular in weight loss supplements because it slows the release of glucose in the bloodstream after a meal.

A study found that instant coffee with chlorogenic acid reduced glucose consumption. These results lead to the theory that chlorogenic acid may reduce body mass and fat. [3]

Olea Europaea Leaf. The leaf of the olive tree contains oleuropein, a chemical compound that may enhance thermogenesis, or heat production in the body. A study on rats found it to increase the thermogenin content in brown adipose tissue as well as adrenaline secretion. [4] This could lead to more energy in your workout, and thus more fat burn.

Caffeine Anhydrous. Caffeine is widely used in supplements because the supplement form is absorbed faster than coffee. Obviously caffeine boosts energy and alertness, but the supplement form can lead to fat burn.

The recommended dosage of caffeine for weight loss is 200 mg 3 times a day. Too much caffeine can lead to nausea, vomiting, insomnia, rapid pulse, dizziness, and shortness of breath.

Higenamine HCL. You may have heard of ephedrine and synephrine. You may also have heard that both can be quite dangerous. Like ephedrine and synephrine, higenamine raises your heart rate and potentially improves athletic performance. Higenamine interacts with the same class of receptors that ephedrine and synephrine do, so it is thought to influence weight loss in the same way, hopefully without the same dangers.

However, higenamine could present its own dangers. It comes from the plant Aconite, which has caused heart-related side effects and even death.

2-hydroxy-2-p-methoxyphenylethyl benzamide. It comes from benzoic acid. Like higenamine, it could activate fat-burning enzymes.

Pausinystalia Yohimbe Bark. Yohimbine is a powerful alkaloid extracted from Yohimbe bark. Supplement makers just can’t get away from it because it stops the body from storing fat when you release adrenaline.

However, Yohimbe has been on the FDA’s list of unsafe herbs since 1997. It comes with many potential side effects, such as dizziness, headache, rapid heartbeat, and nausea. Some side effects are as serious as seizure and even death. As little as 40 mg a day can cause these side effects.

Together with caffeine, yohimbine makes for a very dangerous combination. Be extremely cautious before taking any product with it.

N-Coumaroyldopamine. This is a rare beta 2 agonist because it’s the only one not banned in sports. Found in cocoa and other plants, it has the ability to stimulate the beta 2 adrenoreceptor, increasing muscle mass and decreasing fat mass.

Side effects could include insomnia, increased heart rate, and tremors.

Other ingredients include citric acid, natural and artificial flavors, silicon dioxide, sucralose, acesulfame-K, vegetable stearate, beet juice concentrate powder. These contribute to flavor, but not to fat loss.

Taking Alphamine

To assess tolerance, for the first 2 days you should take 1 scoop of Alphamine mixed with 4 to 5 oz water on an empty stomach 15 to 30 minutes before breakfast. You may take another scoop 5 to 6 hours later. Another scoop may then be added in the morning on day 3.

Do not exceed 3 scoops in a 24 hour period and do not use Alphamine for longer than 8 weeks at a time. Also, drink a lot of liquid while using the product. Be especially careful if you are taking other medications or have medical conditions.

What We Like About Alphamine

Well, if you want to gain muscle and not weight, Alphamine will probably get the job done. It’s packed with powerful ingredients meant to enhance your workout and retain your muscle.

With 84 servings, a container of Alphamine will probably last you about a month.

What We Don’t Like About Alphamine

Alphamine’s ingredients are hidden in several proprietary blends, so it’s impossible to see individual ingredient amounts. These amounts and combinations could prove dangerous. Especially since too much yohimbine and caffeine can be extremely harmful.

Plenty of the ingredients have the potential for undesirable side effects. In particular, many increase heartbeat, which can be extremely dangerous, leading to heart attack and other heart problems.

Probably most importantly, Alphamine isn’t widely reviewed. This could be because it’s a new product, but there aren’t enough comments from consumers to tell whether the product is really effective and safe.

Buying Alphamine

Alphamine comes in two flavors, fruit punch and raspberry lemonade. It costs $59.99 on the official website, PEScience.com, and is just $39.15 at Amazon.com. You can also find it for about $40 at many places, including SupplementWarehouse.com and GymGeneration.com.

Should You Buy Alphamine?

We can’t deny that Alphamine is probably an effective fat burner. However, power usually comes with dangerous side effects, and this is certainly the case with Alphamine. Although it may help you build muscle and burn fat, it may also affect your health.


[1] Sandage, Jr., Bobby W.; Sabounjian, LuAnn A.; Wurtman, Richard J. “Effects of Choline on Athletic Performance and Fatigue.” NIH Workshop on the Role of Dietary Supplements for Physically Active People. June 3-4, 1996. Available from: http://ods.od.nih.gov/pubs/dietphys.pdf#page=100

[2] Mero, Antti A.; Ojala, Tuomo; Hulmi, Juha J.; Puurtinen, Risto; Karila, Tuomo AM; Seppala, Timo. “Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes.” Journal of the International Society of Sports Nutrition. 2010 7. Available from: http://www.jissn.com/content/7/1/1

[3] Thom, E. “The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People.” The Journal of International Medical Research. 2007 35 (6): 900-908. Available from: http://www.ingentaconnect.com/content/field/jimr/2007/00000035/00000006/art00020

[4] Oi-Kano, Yuriko; Kawada, Teruo; Watanabe, Tatsuo; Koyama, Fumihiro; Watanabe, Kenichi; Senbongi, Reijirou; Iwai, Kazou. “Oleuropein, a Phenolic Compound in Extra Virgin Olive Oil, Increases Uncoupling Protein 1 Content in Brown Adipose Tissue and Enhances Noradrenaline and Adrenaline Secretions in Rats.” Journal of Nutritional Science and Vitaminology. 2008 54 (5): 363-370. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19001767