Advanced Post-Workout Support

78%
Doesn't meet expectations

GAT claims Adenoflex increases blood cell mass, which increases muscle mass. There is very little research backing blood support claims, but customer reviews are positive, and those customers seem happy with the available flavors. The affordable price and Bodybuilding.com’s return policy make Adenoflex worth trying at the very least.

  • Ingredient Quality
  • Safety
  • Value
  • Customer Reviews

GAT AdenoFlex is a post-training powder for experienced bodybuilders and athletes looking for a new level of achievement.

GAT claims AdenoFlex supports blood, plasma, and muscle cell expansion to increase muscle size and performance.

Will GAT AdenoFlex really give bodybuilders that extra push? I decided to find out.

The Ingredients

GAT AdenoFlex contains chromium as well as a Cellular Expansion Support Blend, which is broken down below.

Chromium (200 mcg)

Chromium is an essential trace element necessary for health.

In animals, chromium supplementation decreases body fat and increases lean muscle mass [1]. However, researchers find it does not have the same effect on humans.

In one study, football players taking 200 mcg chromium for 9 weeks alongside a program of intensive weight-lifting saw no changes in body composition or strength. [2]

Because the chromium dose used in the human study is the same amount in GAT AdenoFlex, it is likely consumers will see no body composition benefits from this ingredient.

Adenoflex Blood, Plasma & Cellular Expansion Support Blend (7.5 g)

Creatine Monohydrate

Creatine monohydrate is a natural substance that converts to creatine phosphate when ingested. It improves body composition when combined with resistance training.

In one study, 28 healthy men and women participated in a whole-body exercise program 3 days a week for 14 weeks. They either took 5 g creatine monohydrate or a placebo daily. Those taking creatine monohydrate saw an increase in total and fat-free mass, as well as gains in muscle strength. [3]

The subjects in this study received more creatine monohydrate than is probably supplied in the Adenoflex 7.5 g blend, so experiencing the same results is unlikely.

Betaine

Betaine is typically used to treat high levels of homocysteine, a chemical found in the body. High levels of homocysteine are associated with heart disease.

I was not able to find any human studies linking betaine to blood cell or muscle growth. However, there are a few animal studies revealing other properties.

In one pig study, betaine supplementation increased lean fat mass and overall growth. [4] Another animal study showed betaine supplementation increases metabolism in untrained horses, but had no effect on trained horses. [5]

While animal studies are promising, they are not enough to guarantee results in humans.

N-Acetylcysteine

N-acetylecysteine (NAC) comes from the amino acid L-cysteine and is a “building block of protein.”

NAC increases erythropoietin, a blood-building hormone that increases muscle mass. [6]

When taken in doses of 1800 mg NAC supplementation reduces muscle soreness and boosts muscle recovery when taken before and after exercise. [7]

Another study published in the Journal of Molecular Medicine found subjects who supplemented with NAC for 8 weeks lost 5 % of their body fat. Researchers found NAC induced fat loss by reducing insulin’s ability to interact with fat cells. [8]

Dosages were not mentioned so I’m not sure GAT Adenoflex has enough to be effective.

Agmatine Sulfate

Agmatine sulfate is a byproduct of arginine. Essentially, it’s arginine with the carboxylic acid end removed.

In one study, researchers supplemented 110 day-old pigs with arginine for 60 days. Results showed a 5.5% increase in skeletal muscle content and an 11% decrease in fat content. [9]

While animal studies on arginine are promising, I couldn’t find human studies connecting agmatine arginine to muscle growth. This makes me wonder if agmatine is truly effective.

Ursolic Acid

In in vitro study on human cells, ursolic acid supplementation inhibited tyrosine phosphatase and increased glucose uptake. [10]

Mice being fed 500 mg a day for 8 weeks experienced a 24% decrease in weight gain. They also had elevated insulin levels. [11]

Directions and Warnings

Beginners should mix 1 scoop with water and drink immediately after a workout. Once tolerance is built up, take 2 scoops immediately after a workout.

This product is not recommended for those who are under 18, pregnant or nursing, taking medication, or prone to dehydration or overheating.

Side Effects

There are no listed side effects for GAT Adenoflex. However, there are side effects associated with the ingredients, including:

• Skin irritation
• Headaches
• Dizziness
• Nausea
• Mood changes
• Impaired thinking [12]
• Upset stomach
• Diarrhea [13]
• Vomiting
• Constipation [14]

Flavors

GAT Adenoflex comes in two flavors: Grape Bubblegum and Melon Berry.

Reviewers on BodyBuilding.com give Grape Bubblegum 8.1/10 for taste and Melon Berry 9.4/10.

Retailers

There are many retailers offering GAT Adenoflex. Here are the best deals on this product:

BodyBuilding.com:

• $39.63 per tub
• $5.93 shipping
• Allows open returns for in-store credit
• Allows unopened returns for full refund

AllStarHealth.com:

• $31.99 per tub
• Free Shipping
• Allows opened returns containing at least ¼ of powder before 30 days
• Shipping charges not refunded

LuckyVitamin.com:

• $37.89 per tub
• $5.95 shipping
• Only allows unopened returns, must be within 30 days
• Items returned after 30 days will be charged a 20% re-stocking fee

Customer Reviews

BodyBuilding.com is the only retailer with reviews for GAT Adenoflex. Overall, BodyBuilding.com consumers rated this product 9.4/10. There aren’t any negative reviews on the site. Here are a few user opinions:

“Grape is the flavor I am using right now. It tastes good, not overwhelming grape, but just enough. At first I used it as a post, it def helped me recover faster and leave the gym more pumped than normal, I love that you keep your pump after the gym. Lately I’ve been taking it with my preworkout and its crazy, I have the best pumps ever now. One of my freinds got me using Nitraflex and I’ve been hooked on GAT ever since.”

“I think Adenoflex is great! I always look for ways to get better pumps with each workout, this product not only helped me get better pumps but also helped me keep them longer. My veins were popping out and my endurance went up. I liked melon berry flavor the best one out of the two.”

Final Thoughts

GAT claims Adenoflex increases blood cell mass, which increases muscle mass. There is very little research backing blood support claims.

As far as muscle growth, there are a few ingredients that help build muscle. But, I’m not sure there is enough of each ingredient to be effective.

Despite this, customer reviews seem positive, and those customers seem happy with the available flavors. The affordable price and Bodybuilding.com’s return policy make Adenoflex worth further investigation.

References

[1] Anderson, Richard A. “Effects of Chromium on Body Composition and Weight Loss.” Nutrition Reviews (1998). Web. 5 July 2013. http://onlinelibrary.wiley.com/doi/10.1111/j.1753-4887.1998.tb01763.x/abstract.

[2] Clancy, , Clarkson, DeCheke, Nosaka, and Freedson. “Effects of chromium picolinate supplementation on body composition, strength, and urinary chromium loss in football players.” Int J Sport Nutr. (1994). Web. 5 July 2013. http://www.ncbi.nlm.nih.gov/pubmed/8054959.

[3] Brose, Andrea, Gianni Parise, and Mark A. Tarnopolsky. “Creatine Supplementation Enhances Isometric Strength and Body Composition Improvements Following Strength Exercise Training in Older Adults.” The Journals of Gerontology (2002). Web. 5 July 2013. http://biomedgerontology.oxfordjournals.org/content/58/1/B11.short.

[4] Matthews, , Southern, Higbie, Persica, and Bidner. “Effects of betaine on growth, carcass characteristics, pork quality, and plasma metabolites of finishing pigs.” Journal of Animal Science . Web. 5 July 2013. http://www.journalofanimalscience.org/content/79/3/722.short.

[5] Warren, , Lawrence, and Thompson. “The influence of betaine on untrained and trained horses exercising to fatigue.” Journal of Animal Science . Web. 5 July 2013. http://www.journalofanimalscience.org/content/77/3/677.short.

[6] Hildebrandt, Wulf, Steve Alexander, Peter Bärtsch, and Wulf Dröge. “Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity.” Journal of the American Society of Hermatology (2001). Web. 5 July 2013. http://bloodjournal.hematologylibrary.org/content/99/5/1552.short.

[7] Kerksick, , Kreider, and Willoughby. “Intramuscular adaptations to eccentric exercise and antioxidant supplementation.” Amino Acids. (2010). Web. 15 July 2013. http://www.ncbi.nlm.nih.gov/pubmed/19967420

[8] Journal of molecular medicine

[9] Tan, Bie, Yulong Yin, Zhiqiang Liu, Xinguo Li, and Haijun Xu. “Dietary l-arginine supplementation increases muscle gain and reduces body fat mass in growing-finishing pigs.” Amino Acids (2009). Web. 5 July 2013. http://link.springer.com/article/10.1007/s00726-008-0148-0.

[10] Zhang, Wei, Di Hong, Yueyang Zhou, Yinan Zhang, and Qiang Shen. “Ursolic acid and its derivative inhibit protein tyrosine phosphatase 1B, enhancing insulin receptor phosphorylation and stimulating glucose uptake.” Biochimica et Biophysica Acta (BBA) – General Subjects (2006). Web. 5 July 2013. http://www.sciencedirect.com/science/article/pii/S0304416506001607.

[11] Jayaprakasam, Bolleddula, L. Karl Olson, Robert E. Schutzki, Mei-Hui Tai, and Muraleedharan G. Nair. “Amelioration of Obesity and Glucose Intolerance in High-Fat-Fed C57BL/6 Mice by Anthocyanins and Ursolic Acid in Cornelian Cherry (Cornus mas).” J. Agric. Food Chem (2006). Web. 15 July 2013. http://pubs.acs.org/doi/abs/10.1021/jf0520342

[12] “CHROMIUM.” WebMD.com. WebMD, n.d. Web. 5 July 2013. http://www.webmd.com/vitamins-supplements/ingredientmono-932-chromium.aspx?activeIngredientId=932&activeIngredientName=chromium.

[13] “Betaine.” WebMD.com. WebMD, n.d. Web. 5 July 2013. http://www.webmd.com/drugs/drug-1558-betaine+oral.aspx?drugid=1558&drugname=betaine+oral.

[14] “N – ACETYL CYSTEINE.” WebMD.com. WebMD, n.d. Web. 5 July 2013. http://www.webmd.com/vitamins-supplements/ingredientmono-1018-N-ACETYL%20CYSTEINE.aspx?activeIngredientId=1018&activeIngredientName=N-ACETYL%20CYSTEINE.