Advanced Joint Support

Expensive, but effective

Instaflex Joint Support delivers with its ingredients. They’re scientifically tested, and most are proven to be effective. However, for only 90 capsules, Instaflex Joint Support is expensive. Taking 3 a day empties the bottle in just one month. If you can afford the price, it may be worth a try.

  • Ingredient Quality
  • Value
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  • Customer Reviews

Instaflex Joint Support is designed to keep you moving with specially formulated ingredients to relieve joint pain.

Advertised as a “revolutionary joint health formula,” Instaflex Joint Support has 8 key ingredients supposedly backed by scientific testing.

I wanted to find out if this product actually helsp those suffering from joint conditions, so I did some research.

The Instaflex Company

While not much can be found about the history of Instaflex, I learned it is a nutrition, health, and wellness company headquartered in Cambridge, Massachusetts. Instaflex Joint Support was its first product.

The Instaflex Team includes two professional athletes: Doug Flutie and Carla Overbeck. Flutie played for many NFL teams as a quarterback and won many titles, including CFL Player of the Year. Overbeck is one of the most decorated women’s soccer players in the US, and she is in the National Soccer Hall of Fame.

They both use Instaflex Joint Support.

“I have had a very bad back from playing pro football, even having back surgery a year ago. Instaflex has been a tremendous help to me and reduced my pain,” states Flutie on the official Instaflex website.

While endorsement from professional athletes is encouraging, it’s best to examine the formula to anticipate its potential.

Under the Cap

Instaflex Joint Supplement has 8 key ingredients, all listed with individual concentrations, making it easy to judge effectiveness.

Glucosamine Sulfate is the natural fluid around joints. It provides cushioning; once thinned or dissolved, joint friction and subsequent pain and stiffness occur. Glucosamine sulfate is a highly researched ingredient. I found multiple studies supporting its effects.

One in particular followed 106 patients for 3 years while taking 1500 mg glucosamine sulfate.[1] While those given a placebo experienced significant joint-space loss, those given glucosamine sulfate did not.

Glucosamine sulfate is dosed at 1500 mg a day, or 500 mg 3 times daily. This is the exact amount in Instaflex Joint Support.

Methylsulfonylmethane, a form of sulfur, helps form connective tissue in joints. Not much research has been done, but one preliminary study found MSM improved symptoms of pain and physical function from osteoarthritis.[2]

A dose of 500 mg 3 times a day is suggested; Instaflex Joint Support has 500 mg per serving and seems low compared to study suggestions.

White Willow Bark Extract contains salicin, a chemical similar to aspirin. It is has been used historically to reduce pain, but research is still sparse. A study involving 78 participants experienced a moderate painkilling effect after taking 240 mg white willow bark daily.[3]

Anywhere between 120 and 240 mg have been used, though the higher dosage is said to be more effective.[4] Instaflex Joint Support has 250 mg.

Ginger Root Concentrate is an herb that reduces inflammation. Relief and reduced swelling occurred in 75% of patients suffering with osteoarthritis and muscular discomfort.[5] Experts have not agreed on an effective dose of ginger, and Instaflex Joint Support has 240 mg.

Boswellia Serrata Extract , also known as Indian frankincense, has anti-inflammatory properties. It reduces swelling and increases range of motion in joints. All participants in one study who took a boswellia supplement had diminished pain.[6] There is no dosing information at this time, but Instaflex Joint Support employs 125 mg boswellia serrata extract.

Turmeric Root Extract is an anti-inflammatory herb. Studies show turmeric prevented arthritis in mice. However, most studies I found involved animals, making it hard to judge the effect in humans.

Between 400 and 600 mg, 3 times daily is suggested. Instaflex Joint Support only has 50 mg, too low to have the desired effect.

Cayenne 40m H.U. reduces the chemical that carries pain messages to the brain. While testing has shown cayenne to be effective, most have used topical creams. I’m not sure what cayenne in capsule form will do.

Instaflex Joint Support has 50 mg cayenne.

Hyaluronic Acid acts as a cushion and a lubricant to joints, and is supported by testing.[7]

However, hyaluronic acid is normally injected straight into the joint, and Instaflex only contains 4 mg, lower than most effective studies.

Safety Concerns

All of the ingredients in Instaflex Joint Support are considered safe, especially in prescribed doses. The most common side effects came from allergic reactions. Across the board, all ingredients in Instaflex Joint Support may cause nausea and digestive problems.

Those with diabetes should use with caution, as turmeric lowers blood sugar.[8]

Recommended Use

Instaflex Joint Support is simple to use. Take 3 capsules a day with water. No amount is given, but most supplements recommend at least 16 ounces.

Instaflex suggests light exercise and a healthy diet should be used with Instaflex Joint Support for the best results.

Purchasing Instaflex Joint Support

Instaflex Joint Support is offered at multiple reputable online companies, including GNC and the Vitamin Shoppe.

Most websites, including the official website,, retails Instaflex Joint Support at $69.99 a bottle, containing 90 capsules.

StorePriceShippingBuy Now
amazon$38.43FreeBuy Now
vitacost$68.99FreeBuy Now
GNC$69.99FreeBuy Now

A Final Thought

Instaflex Joint Support delivers with its ingredients. They’re scientifically tested, and most are proven to be effective. However, for only 90 capsules, Instaflex Joint Support is expensive. Taking 3 a day empties the bottle in just one month. If you can afford the price, it may be worth a try.


[1] Reginster, J., R. Deroisy, L. Rovati, R. Lee, E. Lejeune, O. Bruyere, G. Giacovelli, Y. Henrotin, J. Dacre, and C. Gossett. “Long-term Effects of Glucosamine Sulphate on Osteoarthritis Progression: A Randomised, Placebo-controlled Clinical Trial.” The Lancet 357.9252 (2001): 251-56. Web.

[2] Kim, L., L. Axelrod, P. Howard, N. Buratovich, and R. Waters. “Efficacy of Methylsulfonylmethane (MSM) in Osteoarthritis Pain of the Knee: A Pilot Clinical Trial1, 2.” Osteoarthritis and Cartilage 14.3 (2006): 286-94. Web.

[3] Schmid, B., Lüdtke, R., Selbmann, H.-K., Kötter, I., Tschirdewahn, B., Schaffner, W. and Heide, L. (2001), Efficacy and tolerability of a standardized willow bark extract in patients with osteoarthritis: randomized placebo-controlled, double blind clinical trial. Phytother. Res., 15: 344–350. doi: 10.1002/ptr.981

[4] “Willow Bark.” WebMD. Available from:

[5] Srivastava, K.C., and T. Mustafa. “Ginger (Zingiber Officinale) in Rheumatism and Musculoskeletal Disorders.” Medical Hypotheses 39.4 (1992): 342-48. Web.

[6] Kimmatkar, N. “Efficacy and Tolerability of Extract in Treatment of Osteoarthritis of Knee ? A Randomized Double Blind Placebo Controlled Trial.” Phytomedicine 10.1 (2003): 3-7. Web.

[7] Swann, D. A., E. L. Radin, M. Nazimiec, P. A. Weisser, N. Curran, and G. Lewinnek. “Role of Hyaluronic Acid in Joint Lubrication.” Annals of the Rheumatic Diseases 33.4 (1974): 318-26. Web.

[8] “Turmeric.” University of Maryland Medical Center. Available from: